The rise of genomic studies in Africa – not least due to projects funded under H3Africa – is associated with the development of a small number of biorepositories across Africa. For the ultimate success of these biorepositories, the creation of cell lines including those from selected H3Africa samples would be beneficial. In this paper, we map ethical challenges in the creation of cell lines.

Background The rise in genomic and biobanking research worldwide has led to the development of different informed consent models for use in such research. This study analyses consent documents used by investigators in the H3Africa (Human Heredity and Health in Africa) Consortium. Methods A qualitative method for text analysis was used to analyse consent documents used in the collection of samples and data in H3Africa projects. Thematic domains included type of consent model, explanations of genetics/genomics, data sharing and feedback of (...) test results. Results Informed consent documents for 13 of the 19 H3Africa projects were analysed. Seven projects used broad consent, five projects used tiered consent and one used specific consent. Genetics was mostly explained in terms of inherited characteristics, heredity and health, genes and disease causation, or disease susceptibility. Only one project made provisions for the feedback of individual genetic results. Conclusion H3Africa research makes use of three consent models—specific, tiered and broad consent. We outlined different strategies used by H3Africa investigators to explain concepts in genomics to potential research participants. To further ensure that the decision to participate in genomic research is informed and meaningful, we recommend that innovative approaches to the informed consent process be developed, preferably in consultation with research participants, research ethics committees and researchers in Africa. (shrink)

The concept of Smart Healthy Age-Friendly Environments (SHAFE) emphasises the comprehensive person-centred experience as essential to promoting living environments. SHAFE takes an interdisciplinary approach, conceptualising complete and multidisciplinary solutions for an inclusive society. From this approach, we promote participation, health, and well-being experiences by finding the best possible combinations of social, physical, and digital solutions in the community. This initiative emerged bottom-up in Europe from the dream and conviction that innovation can improve health equity, foster caring communities, and sustainable development. (...) Smart, adaptable, and inclusive solutions can promote and support independence and autonomy throughout the lifespan, regardless of age, gender, disabilities, cultural differences, and personal choices, as well as promote happier and fairer living places. The New European Bauhaus initiative gathers “beautiful, sustainable, and inclusive projects and ideas” to inspire a positive transformation around us. The New European Bauhaus 2024 Festival took place between 9-13 April. “Designing the perfect New European Bauhaus neighbourhood: New European Bauhaus meets SHAFE” was a Satellite Event of the Festival, held as an online workshop, organised by the SHAFE Foundation on April 9th, 2024. At the event, a group of 50 participants with a multidisciplinary background discussed how to meet the challenges of the European Garcia family to enable them to live in a perfect neighbourhood. The White Paper presents the findings of the participants with the New European Bauhaus inspiring projects and ideas to house the European Garcia family in their neighbourhood. The White Paper recommends developers, designers, planners, and policymakers to include person-centred design of social and physical environments and technologies. Although awareness of person-centred design is growing, many initiatives still hamper the inclusion of citizens or end-users throughout the development of products and services. (shrink)

Intended for introductory classes focusing on philosophy of mind, 'Theories of Mind' includes readings from primary sources, edited to suit the needs of the beginner. Selections focus on vivid examples and counterexamples, and give instructors concerned with assigning accessible primary source material a foundation for more advanced studies in philosophy. Selections from David Armstrong, Ned Block, David Chalmers, Patricia Churchland, Paul Churchland, Andy Clark, Daniel C. Dennett, René Descartes, Jerry A. Fodor, Keith Gunderson, Frank Jackson, David Lewis, Barbara Montero, (...) Thomas Nagel, Gilbert Ryle, John Searle, J. J. C. Smart, and Alan M. Turing are included. (shrink)

Can Boyer's model of ownership psychology provide useful insights for comparative research? I apply his model to argue that we currently have evidence for possession psychology (based on competitive resource acquisition) in non-human primates, but not for ownership psychology.

A medical information commons is a networked data environment utilized for research and clinical applications. At three deliberations across the U.S., we engaged 75 adults in two-day facilitated discussions on the ethical and social issues inherent to sharing data with an MIC. Deliberants made recommendations regarding opt-in consent, transparent data policies, public representation on MIC governing boards, and strict data security and privacy protection. Community engagement is critical to earning the public's trust.

Nursing practice invites nurses to embody caring practices that meet, comfort and empower vulnerable others. Such a practice requires a commitment to meeting and helping the other in ways that liberate and strengthen and avoid imposing the will of the caregiver on the patient. Being good and acting well (phronesis) occur in particular situations. A socially constituted and embodied view of agency, as developed by Merleau‐Ponty, provides an alternative to Cartesian and Kantian views of agency. A socially constituted, embodied view (...) of agency is less mechanistic and less deterministic than Descartes' and Kant's radical separation of mind and body, and more responsive and generative than Kant's vision of moral agency as constituted by autonomous choice makers who are uninfluenced by emotion. The role of emotion in perception and judgement is explored in this paper. Distinctions between techne and phronesis are drawn. The role of emotion in market relationships and procedural ethics drawn for the abstract, general other are strategies for exchange of goods and services, but these same market relationships are dependent on well‐functioning nonmarket relations of noncalculated giving and receiving. (shrink)

In general, stimuli that are familiar and recognizable have an advantage of predominance during binocular rivalry. Recent research has demonstrated that familiar and recognizable stimuli such as upright faces and words in a native language could break interocular suppression faster than their matched controls. In this study, a visible word prime was presented binocularly then replaced by a high-contrast dynamic noise pattern presented to one eye and either a semantically related or unrelated word was introduced to the other eye. We (...) measured how long it took for target words to break from suppression. To investigate word-parts priming, a second experiment also included word pairs that had overlapping subword fragments. Results from both experiments consistently show that semantically related words and words that shared subword fragments were faster to gain dominance compared to unrelated words, suggesting that words, even when interocularly suppressed and invisible, can benefit from semantic and subword priming. (shrink)

Psychopaths are agents who lack the normal capacity to feel moral emotions (e.g. guilt based on empathy with the victims of their actions). Evidence for attributing psychopathy at least in some cases to genetic or early childhood causes suggests that psychopaths lack free will. However, the paper defends a sense in which psychopaths still may be construed as responsible for their actions, even if their degree of responsibility is less than that of normal agents. Responsibility is understood in Strawsonian terms, (...) as a question of our appropriate reactive attitudes toward an agent for what she does, and as distinct from the question of the agent's own motivating attitudes, which lead him to do what he does. The latter is the question more directly relevant to free will, though moral motivation normally depends on the capacity in early childhood to pick up motivating attitudes from others' reactive attitudes. Reactive attitudes based on hatred rather than anger (e.g. disgust or contempt) count as alternative forms of blame that may be appropriately directed toward agents manifesting bad qualities of will, even as a matter of motivational impairment. So psychopaths may still be said to deserve blame, even if they are incapable of modifying their behavior in response to blame. (shrink)

Interweaves elements of Kristevan and Heideggerian thought in order to reconstruct a linguistically embedded, existentially and affectively rich, dialectical model of willed self-regulation.

'During the course of the seventeenth century, within the scholastic tradition itself, commentaries on Aristotle's natural philosophical works increasingly gave way to textbooks and compendia organized along thematic lines' (Dear 1985, 161).

This book explains how P4C can facilitate young people's exploration of key ethical concerns of our time, such as sustainability, justice and intercultural and ...

Clinical next generation sequencing is a term that refers to a variety of technologies that permit rapid sequencing of large numbers of DNA segments, up to and including entire genomes. As an approach that is playing an increasingly important role in obtaining genetic information from patients, it may be viewed by public and private payers either positively, as an enabler of the promised benefits of personalized medicine, or as “the perfect storm” resulting from the confluence of high market demand, an (...) uproven technology, and an unprepared delivery system. A number of recent studies have noted that coverage and reimbursement will be critical for clinical integration of NGS, yet the evidentiary pathway for payer decision-making is unclear. Although there are multiple reasons for this uncertain reimbursement environment, the situation stems in large part from a long-standing lack of alignment between the information needs of regulators and post-regulatory decision-makers such as payers. (shrink)

This book explores Gilles Deleuze's contribution to film theory. According to Deleuze, we have come to live in a universe that could be described as metacinematic. His conception of images implies a new kind of camera consciousness, one that determines our perceptions and sense of selves: aspects of our subjectivities are formed in, for instance, action-images, affection-images and time-images. We live in a matrix of visual culture that is always moving and changing. Each image is always connected to an assemblage (...) of affects and forces. This book presents a model, as well as many concrete examples, of how to work with Deleuze in film theory. It asks questions about the universe as metacinema, subjectivity, violence, feminism, monstrosity, and music. Among the contemporary films it discusses within a Deleuzian framework are Strange Days, Fight Club, and Dancer in the Dark. (shrink)

The category of emotions covers a disputed territory, but clear examples include fear, anger, joy, pride, sadness, disgust, shame, contempt and the like. Such states are commonly thought of as antithetical to reason, disorienting and distorting practical thought. However, there is also a sense in which emotions are factors in practical reasoning, understood broadly as reasoning that issues in action. At the very least emotions can function as "enabling" causes of rational decision-making (despite the many cases in which they are (...) disabling) insofar as they direct attention toward certain objects of thought and away from others. They serve to heighten memory and to limit the set of salient practical options to a manageable set, suitable for "quick-and-dirty" decision-making. (shrink)

Until recently, business issues in healthcare organizations were relatively insulated from clinical issues, for several reasons. The hospital at earlier stages of its development operated on a combination of charitable and equitable premises, allowing for providing care to be separated from financial support. Physicians, who were primarily responsible for clinical care, constituted an independent power nexus within the hospital and were governed by their own professional codes of ethics. In exchange for a great deal of control over their conditions of (...) practice, they took almost complete responsibility for patient care. Thus clinical and professional ethics could to some extent be compartmentalized from the business issues—a much easier feat when, as in much of the last few decades, virtually all care was reimbursed from some source or other. In addition, many HCOs were not categorized or treated as businesses, although of course they were presumed to be governed by the same expectation for good management as any other organization. (shrink)

This paper argues that corporate governance reformers in Anglo-American jurisdictions should consider a different approach in their quest for better corporate governance. Traditionally, corporate governance reform has taken a structural approach, tightening the rules around the number of independent directors required on boards and committees and fine-tuning the definition of independence. However, such an approach has failed to achieve effective corporate governance. Moreover, this approach is informed by the arguably discredited assumption that individuals are rational self-interest utility maximizers. This conceptual (...) paper questions why corporate governance scholars and regulators remain uncritical of this assumption and suggests an approach to reform inspired by a different view of human nature. Indeed, incorporating an actor-based approach to reform into existing structures may better achieve effective corporate governance while addressing an unjustified adherence to this flawed assumption. (shrink)

The papers from the 2000 symposium of the Royal Society of Canada explore the crucial relationship between science and ethics.

Child welfare clinics established in a rural Jamaican community for research purposes are described. These special clinics were able to devote more resources to the care of their children than is usual, yet the growth and health of these children were very similar to those in another group to whom this service was not available and who attended routine government welfare clinics only infrequently.

The main purpose of this article consists in discussing the idea of moral responsibility in Abraham’s case as it is put forward in Fear and Trembling. With this idea in mind, the notion of ethical heteronomy that the author defends is opposed to kantian ethical autonomy. From this viewpoint, religious sacrifice not only cannot but also must not be ethically justified. The discussion is developed considering Kierkegaard’s ideas from the perspective of different contemporary ethical theories.

This article is devoted to analyze the kierkegaardian concept of original Sin with the main purpose of highlighting that, even though Kierkegaard uses some resources “analogous” to analytical philosophy, the results are not connected with this tradition of thought. Existential concepts are presen..

El objetivo de este artículo es analizar dos modelos complementarios de laicización de la cultura formulados a principios del siglo XX a partir de la confrontación con el paradigma religioso, a saber: el psicoanálisis freudiano y el socialismo del joven Gramsci. La hipótesis que conduce el análisis es la siguiente: la comprensión gramsciana del problema de la cultura introduce la dimensión política desconocida en los escritos antropológicos de Freud. Es la introducción de esta dimensión la que explica que Gramsci no (...) describa la función de la religión a partir de la consideración del cristianismo en términos generales, como hace Freud, sino que estudie la función de la Iglesia Católica en el proceso italiano de unificación nacional conocido como Risorgimento. (shrink)

Hutcheson’s theory of morality shares far more common ground with Clarke’s morality than is generally acknowledged. In fact, Hutcheson’s own view of his innovations in moral theory suggest that he understood moral sense theory more as an elaboration and partial correction to Clarkean fitness theory than as an outright rejection of it. My aim in this paper will be to illuminate what I take to be Hutcheson’s grounds for adopting this attitude toward Clarkean fitness theory. In so doing, I hope (...) to bring to light an otherwise unexpected continuity between moral sense theory and the moral rationalism to which it is usually opposed, and, in so doing, draw attention to the anti-sceptical realism that lies at the heart of both accounts. (shrink)

This paper focuses on the interpretation of the Italian approximative adverb quasi 'almost' by primarily looking at cases in which it modifies temporal connectives, a domain which, to our knowledge, has been largely unexplored thus far. Consideration of this domain supports the need for a scalar account of the semantics of quasi (close in spirit to Hitzeman's semantic analysis of almost, in: Canakis et al. (eds) Papers from the 28th regional meeting of the Chicago Linguistic Society, 1992). When paired with (...) suitable analyses of temporal connectives, such an account can provide a simple explanation of the patterns of implication that are observed when quasi modifies locational (e. g. quando 'when'), directional (e. g. fino 'until' and da 'since'), and event-sequencing temporal connectives (e. g. prima 'before' and dopo ' after'). A challenging empirical phenomenon that is observed is a contrast between the modification of fino and da by quasi, on the one hand, and the modification of prima and dopo by the same adverb, on the other. While quasi fino and quasi da behave symmetrically, a puzzling asymmetry is observed between quasi prima and quasi dopo. To explain the asymmetry, we propose an analysis of prima and dopo on which the former has the meaning of the temporal comparative più presto 'earlier', while the latter is seen as an atomic predicate denoting temporal succession between events (Del Prete, Nat Lang Semantics 16: 157-203, 2008). We show that the same pattern of implication observed for quasi prima is attested when quasi modifies overt comparatives, and propose a pragmatic analysis of this pattern that uniformly applies to both cases, thus providing new evidence for the claim that prima is underlyingly a comparative. A major point of this paper is a discussion of the notion of scale which is relevant for the semantics of quasi', in particular, we show that the notion of Horn (entailment-based) scale is not well-suited for handling modification of temporal connectives, and that a more general notion of scale is required in order to provide a uniform analysis of quasi as a cross-categorial modifier. (shrink)

The exportation of Western biomedicine throughout the world has not resulted in a systematic homogenization of scientific ideology but rather in the proliferation of many forms and practices of biomedicine. Similarly, in the last decade, bioethics has become increasingly an international enterprise. Although there may be consensus regarding the inherent value of ethical discourse as it relates to health and medical care, there are disagreements about the nature and parameters of medical morality. This lack of consensus exists because our beliefs (...) about morality are culturally constituted, embedded in social, religious, and political ideologies that influence particular individuals and communities at specific historical moments. (shrink)

Most people believe that extraterrestrial beings or porpoises or computers could someday be recognized as persons. Given the significant constitutional differences between these entities and ourselves, the general assumption appears to be that ‘person’ is not a natural kind term. David Wiggins offers an illuminating challenge to this popular dogma in ‘Locke, Butler and the Stream of Consciousness: and Men as a Natural Kind’. Wiggins does not claim that ‘person’ actually is a natural kind term; but he argues hard for (...) the advantages of regarding it as something like a natural kind classification. The problem is that, whatever its merits, there are obvious and fatal objections to the view that person is a natural kind. My aim is to present a modification of the natural kind thesis which avoids these objections and retains the attractions of the basic position. (shrink)

I first began working on emotions as a project in philosophy of action, without particular reference to moral philosophy. My thought was that emotions have a distinctive role to play in rationality that tends to be underappreciated by philosophers. Bringing this out was meant to counter a widespread tendency to treat emotions as “blind” causes of action (for the general picture, see Greenspan 2009.) Instead, I thought that emotions could be seen as providing reasons. I took their significance as moral (...) motivators to be hard to miss. Of course, philosophers and others sometimes rightly insist that we need to put emotions aside in order to formulate satisfying moral principles, but I would have been surprised to hear anyone deny that moral motivation typically rests on emotion and that we need that basis in early life in order to get to the stage of acting on moral principles. However, I have since come to think that none of the main philosophical approaches to ethics fully appreciates the significance of emotion, in part because of a misconception of practical reasons. Reasons for action are commonly taken as prima facie requirements, so that moral reasons would yield requirements just insofar as they outweigh competing reasons such as reasons of simple self-interest. Someone who recognizes a moral reason as holding “all things considered” would be irrational not to act on it. But I argue in recent work (starting with Greenspan 2005) that even all-things-considered reasons may in one sense be optional: a rational agent can legitimately “discount” them, cancelling their deliberative weight and their force for motivation. What keeps us from setting aside reasons of the sort that underlie moral.. (shrink)

Locke's moral theory consists of two explicit and distinct elements — a broadly rationalist theory of natural law and a hedonistic conception of moral good. The rationalist account, which we find most prominently in his early Essays on the Law of Nature, is generally taken to consist in three things. First, Locke holds that our moral rules are founded on universal, divine natural laws. Second, such moral laws are taken to be discoverable by reason. Third, by dint of their divine (...) authorship, moral laws are obligatory and rationally discernible as such. Locke's hedonism, which is developed most fully in his later Essay Concerning Human Understanding, consists in the view that all good amounts to pleasure, with specifically moral good taken to consist in the pleasurable consequences of discharging one's moral duties. (shrink)

Locke's moral theory consists of two explicit and distinct elements — a broadly rationalist theory of natural law and a hedonistic conception of moral good. The rationalist account, which we find most prominently in his early Essays on the Law of Nature, is generally taken to consist in three things. First, Locke holds that our moral rules are founded on universal, divine natural laws. Second, such moral laws are taken to be discoverable by reason. Third, by dint of their divine (...) authorship, moral laws are obligatory and rationally discernible as such. Locke's hedonism, which is developed most fully in his later Essay Concerning Human Understanding, consists in the view that all good amounts to pleasure, with specifically moral good taken to consist in the pleasurable consequences of discharging one's moral duties. (shrink)

Sex determination offers an opportunity to address many classic questions of developmental biology. In addition, because sex determination evolves rapidly, it offers an opportunity to investigate the evolution of genetic hierarchies. Sex determination in Drosophila melanogaster is controlled by the master regulatory gene, Sex lethal (Sxl). DmSxl controls the alternative splicing of a downstream gene, transformer (tra), which acts with tra2 to control alternative splicing of doublesex (dsx). DmSxl also controls its own splicing, creating an autoregulatory feedback loop that ensures (...) expression of Sxl in females, but not males. A recent paper1 has shown that in the dipteran Ceratitis capitata later (downstream) steps in the regulatory hierarchy are conserved, while earlier (upstream) steps are not. Cctra is regulated by alternative splicing and apparently controls the alternative splicing of Ccdsx. However, Cctra is not regulated by CcSxl. Instead it appears to autoregulate in a manner similar to the autoregulation seen with DmSxl. BioEssays 25:1–4, 2003. © 2002 Wiley Periodicals, Inc. (shrink)

Suppose I am now making plans for next summer’s vacation. I can spend a week in Rome or on the Riviera, but not both. Either choice would be excellent, but after weighing various pros and cons, I decide that for my purposes Rome would be better. If I am rational, then, I must choose Rome. It is an assumption of standard decision theory that rationality requires maximizing: trying to get the maximum amount of whatever form of value we are after (...) (usually construed as “utility”). An alternative has been proposed, under the heading of “satisficing” – being satisfied with what suffices, as it were, or settling for an option that is “good enough” – but this may seem rational only when there are costs to determining which option is best that diminish the value of choosing it, to the point where the choice of a less good option really amounts to maximizing. Where there is no serious cost, even in time and effort, to getting hold of something better – a vacation in Rome rather than the Riviera – how could it be rational to turn it down? If we pay attention to the temporal standpoint from which a choice is made, though, satisficing makes good sense. It accords with our common appeal to thresholds: adequate levels of satisfaction or value, such that getting above them is not necessary, though it might be nice. Once we have reached a threshold, it is rational – meaning rationally permissible – to stop. Pushing further toward the best may also be permissible but is not rationally required, where we already have a good enough option in hand. So if offered a chance to move to Rome while already settled happily on the Riviera, I would not be irrational to turn the offer down, even if I grant that accepting it would make my vacation even better. (shrink)